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FLYNN HEALTH UBIQUINOL

8/17/2017 7:31:24 PM

AUST L 267536

Active Formulation

IngredientDose/CapsuleDose/Day
Coenzyme Q10 (Ubiquinol-10) 50 mg 100 mg
Recommended Daily Dose: Take 1 capsule twice daily.

Therapeutic Indications and Highlights

  • Ubiquinol is the reduced from of coenzyme Q10
  • Antioxidant
  • Supports cellular energy production
  • Supports cardiovascular health
  • Supports immune function
  • Convenient capsule format for flexible prescribing
  • Can be used as a supplemental form of Coenzyme Q10; the amount of Coenzyme Q10 in the body decreases with age

Coenzyme Q10

Coenzyme Q10 (CoQ10), also known as ubiquinone, is a powerful, fat-soluble antioxidant and its primary function is as a cofactor in the electron transport chain, which is a series of oxidation-reduction reactions involved in cellular respiration and ATP synthesis. As an antioxidant, CoQ10 is a scavenger of reactive oxygen species and stabilises cell membranes, preserving cellular integrity and function.[1]

Although CoQ10 can be synthesised in the body, our ability to do so declines with age. As the diet may only supply approximately 3-5mg per day,[2] supplementation may be required to obtain therapeutic benefits.

Ubiquinol vs Ubiquinone

CoQ10 undergoes a reduction reaction in order to be converted from ubiquinone into ubiquinol (Figure 1);  in humans, about 95% of CoQ10 is in the form of ubiquinol.[3]  Ubiquinone is relatively poorly absorbed due to its hydrophobic nature and large molecular size.[4] 

Figure 1: Molecular Structure of CoQ10 [5]

Figure 1

Energy Production

CoQ10 plays a vital role in intracellular energy production as a cofactor in the mitochondrial electron transport chain (respiratory chain) and is therefore essential for the production of ATP.  CoQ10 functions as a mobile redox agent shuttling electrons and also protons in the electron transport chain (Figure 2). [6] Due to this fundamental role in cellular bioenergetics, CoQ10 is concentrated in tissues that have a high-energy requirements such as the brain, heart, kidney, and liver.[7]

 Figure 2: Mitochondrial Electron Transport Chain [8]

Figure 2

Cardiovascular Health

CoQ10 is particularly important for cardiovascular health and enhancement of myocardial function due to its effects on enhancing energy production, improving contractility of the cardiac muscle, providing potent antioxidant activity for the prevention of LDL oxidation.[9] 

Antioxidant

In its reduced form as ubiquinol, CoQ10 is a powerful antioxidant that prevents oxidative damage by free radicals, including oxidation of lipids within the mitochondrial membrane. CoQ10 also serves as an antioxidant by activating and increasing expression of mitochondrial uncoupling proteins (UCPs), an effect which is antiapoptotic and leads to a reduction in free radical generation.[10]  Furthermore, CoQ10 is capable of recycling and regenerating other antioxidants such as vitamins C and E.[11]

Warnings

  • If symptoms persist consult your healthcare practitioner (or words to that effect)
  • Do not take while on warfarin therapy without medical advice

Endnotes

  • 1 Alternative Medicine Review. Coenzyme Q10. Thorne Research Inc. Vol 3, No. 1, 1998
  • 2 Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric Disease and Treatment. 2009;5:597-610.
  • 3 Bhagavan HN, Chopra RK, Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006
  • 4 Braun L, Cohen M. Coenzyme Q10, Herbs and Natural Supplements An Evidence Based Guide, Vol 2. 3rd ed. Elsevier. 2015
  • 5 https://examine.com/supplements/coenzyme-q10
  • 6 Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric Disease and Treatment. 2009;5:597-610.
  • 7Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric Disease and Treatment. 2009;5:597-610.
  • 8Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatric Disease and Treatment. 2009;5:597-610.
  • 9Alternative Medicine Review. Coenzyme Q10. Thorne Research Inc. Vol 3, No. 1, 1998
  • 10 Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease.Neuropsychiatric Disease and Treatment. 2009;5:597-610.
  • 11Bhagavan HN, Chopra RK, Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics . Free Radic Res. 2006